Co-administration of indacaterol and tiotropium bromide for the treatment of chronic obstructive pulmonary disease and bronchiectasis, and effect on IL-8 and CRP levels

Purpose: To investigate the efficacy of indacaterol plus tiotropium bromide in chronic obstructive pulmonary disease (COPD) complicated by bronchiectasis and impact on IL-8 C reactive protein (CRP) levels.Methods: Sixty enrolled patients with COPD who received treatment Yantai Qishan Hospital, Yuyan, China from June 2017 to December 2019 were randomly allocated group A (n = 30) B 30). Group inhalation bromide. only therapy. Therapeutic effects appropriate serum indicators compared.Results: Maximal mid-expiratory flow (MMF), maximal voluntary ventilation (MVV), forced expiratory volume one second (FEV1.0) levels significantly elevated, showed a higher values than (p < 0.05). The IL-8, CRP, calcitonin (PCT) both groups lower before treatment, but decrease was greater that SaO2, PaO2, PaO2/FiO2 increased, increase total incidence complications 0.05).Conclusion: Indacaterol produced significant bronchiectasis, which ameliorate lung function inflammation status body therefore have potential being utilized clinical practice.